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KMID : 0438420080150020117
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Korean Journal of Bone Metabolism
2008 Volume.15 No. 2 p.117 ~ p.126
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The Relationship between Bone Mineral Density and Atherosclerotic Parameters in Postmenopausal Women with Diabetes
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Kim Ji-Yon
Roh Mi-Oh
Song Min-Soo
Jung Chan-Hee
Jung Jung-Hwa
Park Hyeong-Kyu
Kim Yei-Ju
Mok Ji-Oh
Kim Sang-Jin
Kim Chul-Hee
Seo Kyo-Il
Yoo Myung-Hi
Byun Dong-Won
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Abstract
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Objective: Recent studies suggest a possible pathogenic linkage between the osteoporosis and atherosclerosis. Both osteoporosis and atherosclerosis, responsible for significant morbidity and mortality, are independent predictors of
cardiovascular disease. They may share common regulatory mechanisms as well as histopathology. In this study, we
want to show the relationship between bone mineral density (BMD) and atherosclerotic parameters in postmenopausal
women with diabetes.
Methods: Total 60 postmenopausal women with diabetes were enrolled in this study. We measured pulse wave velocity (PWV), carotid intima-media thickness (IMT) and carotid plaque as atherosclerotic parameters. We also checked
anthropometric and serologic markers including HbA1C, C-peptide, lipid profiles and bone markers. The lumbar spine,
femur neck and total hip BMD was measured using dual energy X-ray absorptiometry (DXA).
Results: The prevalence of carotid plaque in our study is 30%. According to increasing of age, serum calcium (P=0.012), aortic PWV (P=0.002) and mean IMT (P=0.024) are significantly increased. BMD is significantly decreased by increased duration of diabetes, not by HbA1C level. Lipid profile, IMT, PWV are not correlated with BMD. Only patients with
presence of carotid plaque showed significantly decreased lumbar spine BMD (P=0.048), increased duration of diabetes
(P=0.033) and aortic PWV (P=0.001) compared to those with absence of plaque.
Conclusion: Out of many atherosclerotic parameters, only carotid plaque showed significantly decreased lumbar spine BMD.
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KEYWORD
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Atherosclerosis, Bone mineral density, Carotid artery plaque, Diabetes mellitus, Osteoporosis
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